Current Landscape of Hyaluronic Acid Filler Use in the United States

Summary: Hyaluronic Acid (HA) fillers are among the most used dermal fillers for soft-tissue augmentation. The various permutations of new formulations approved by the FDA for HA fillers have made it difficult for clinicians to select the appropriate filler for the corresponding cutaneous defect. HA dermal fillers have promising use for atrophic scars 2/2 to surgery, postsurgical asymmetry, atrophy from radiation therapy, and wound healing. Skinvive, an intradermal microdroplet HA filler, has shown greater efficacy and less need for re-treatments. Fillers with higher HA concentration and cross-linking are more efficacious for deeper injections and deeper wrinkles. Long term comparator studies should evaluate the efficacy of various dosage forms compared to traditional HA filler injections.