Demographic and Histologic Study of Patients with Perforating Dermatoses- Seven-Year Retrospective Study

Summary: Background: Perforating dermatoses are rare skin disorders characterized by dermal elements extruding through the epidermis. This study focuses on perforating folliculitis and reactive perforating collagenosis, both linked to diabetes and chronic kidney disease (CKD). While their histopathological features are well-defined, data on prevalence and clinical patterns remain limited. This research aims to evaluate the demographic, clinical, and histological characteristics of patients with these conditions. Methods: A retrospective study over seven years (2017-2024) was conducted at Razi Dermatology Hospital, including 100 patients aged 15-85. Data on demographics, clinical presentations, comorbidities, and histopathological findings were analyzed using SPSS version 22. Results: The cohort comprised 52 females (52%) and 48 males (48%), with a mean age of 49.7 years. Diabetes was the most common comorbidity (55%), followed by CKD (25%). Perforating folliculitis was diagnosed in 71 patients (71%), exhibiting follicular dilation and inflammatory infiltration. Reactive perforating collagenosis was present in 29 patients (29%), marked by keratotic plugs and collagen degeneration. Lesions primarily affected the lower extremities (51%). Conclusion: This study highlights the association of perforating dermatoses with systemic conditions, affirming the need for comprehensive management strategies.