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Frambesiform Axillary Mass

Dean Holliday

Guru | Pathology, Dermatopathology

Presented at: 28th Joint Meeting of the ISDP

Date: 2025-03-05 00:00:00

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Summary: Porocarcinoma(PC) is a rare adnexal tumor originating from the acrosyringium, with some estimates of porocarcinoma accounting for 0.005-0.01% of all malignant cutaneous neoplasms. The most common sites involved are the head and neck (39.9%), lower extremities (33.9%), trunk (16.9%) and upper extremities (8.8%), Amongst the sites of the trunk, the most common sites are the back and chestwall. The incidence of PC is highest in older individuals and management typically includes surgical removal; however, prognosis is poor, with PC recurring after treatment in 35% of cases. PC has regional metastatic rates of ~20% and distant metastasis occurs in 12% of cases, with patients who develop distant metastasis having a mortality rate of 64%. Histologically PC may have significant overlap with benign entities such as poromas, dermal duct tumors, and other basaloid epithelial lesions, however areas with infiltrative growth, spontaneous necrosis, and the presence of ductal structures are helpful in establishing the diagnosis. Here we present a case of porocarcinoma, presenting as a frambesiform mass in the axilla of a 54-year-old male with no significant past medical history and no family history of carcinoma.