Transforming Cancer Care: Real-Time Adaptation in Stereotactic Body Radiotherapy (SBRT) Using MR-Linacs for Enhanced Outcomes in Pancreatic and Prostate Tumors

Summary: This study aims to evaluate the clinical impact of Magnetic Resonance Image-Guided linear Accelerators (MR-Linacs) in stereotactic body Radiotherapy (SBRT) for patients with pancreatic and prostate tumours. The focus is on assessing real-time adaptation capabilities and their effects on treatment outcomes A retrospective analysis was conducted on patients diagnosed with pancreatic or prostate cancer who underwent SBRT using MR-Linacs between January 2022 and December 2023. Treatment planning involved real-time MRI imaging to adapt radiation delivery according to tumor motion and patient anatomy changes. Key metrics analyzed included treatment accuracy, toxicity profiles, and overall patient outcomes, measured by local control rates and quality of life assessments A total of 100 patients were included in the study (60 pancreatic and 40 prostate cancer cases). The use of MR-Linacs resulted in a significant reduction in radiation exposure to surrounding healthy tissues, with a mean decrease of 30% in dose to organs at risk. Local control rates at six months post-treatment were 85% for pancreatic tumors and 90% for prostate tumors. Patient-reported outcomes indicated improved quality of life scores, particularly in gastrointestinal and urinary function, with a reduction in acute toxicity events by 40% compared to historical controls MR-Linacs demonstrate substantial promise in enhancing treatment precision and patient outcomes in SBRT for pancreatic and prostate cancers. The ability to adapt treatment in real-time significantly reduces toxicity while maintaining high local control rates. These findings support the integration of MR-guided technologies into routine clinical practice for improved cancer care Moufiq AH. Aboulqassim (he/him/his), n/a (Presenting Author) - Abdullah Thafer Hospital; Ayman AH. Aboulqassim (he/him/his), n/a (Co-Author) - Abdullah Thafer Hospital