The Role of GLI1-ISH in the Diagnostically Challenging Basal Cell Carcinoma
Martha Chavez
Guru | Pathology, Anatomic Pathology, Clinical Pathology
Presented at: 28th Joint Meeting of the ISDP
Date: 2025-03-05 00:00:00
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Summary: Basal cell carcinoma (BCC) and basaloid squamous cell carcinoma (basaloid SCC) are morphologically similar, often presenting diagnostic challenges.
In situ hybridization (ISH) for glioma-associated oncogene homolog 1 (GLI1) is a helpful diagnostic tool for these cases.
GLI1 expression is specific to BCC and is typically absent or minimally expressed in basaloid SCC
We aim to validate the use of GLI1-ISH in distinguishing BCC from basaloid SCC by analyzing four diagnostically challenging and unusual cases.