Association between psoriasis and skin cancer: Cross-sectional analysis

Summary: Abstract Body: Psoriasis is a chronic autoimmune skin disorder that affects the extensor surfaces, scalp, and lumbosacral region, it is characterized by erythematous plaques with silvery-white scale. Proinflammatory cytokines, including tumor necrosis factor-alpha, dendritic cells, and T-cells, play a crucial role in its pathogenesis and disease progression. The chronic inflammatory dysregulation seen in psoriasis can predispose patients to secondary diseases. The National Institutes of Health's (NIH) All of Us (AoU) program—a nationwide effort aimed to engage underrepresented populations in biomedical research— provides a unique framework for studying the association between psoriasis and skin cancer. Participants with psoriasis (n = 7,377; mean age 63.4 years; 59.2% female) were matched to controls based on sex, age, race/ethnicity, income, and education. Fisher’s exact test was applied to analyze categorical variables, and an unpaired t test was used for continuous variables. Logistic regression models were developed to calculate the odds ratio. Results demonstrated a significant increase in the odds of having BCC (OR: 2.18, 95% CI: [2.04, 2.32], p < 0.01), SCC (OR: 2.22, 95% CI: [2.02, 2.45], p < 0.01), and malignant melanoma (OR: 1.73, 95% CI: [1.52, 1.97], p < 0.01) after adjusting for confounders. Amritpal Kooner¹, Rawle Sekhon², Beniamin Zeka¹, Michelle Anthony³ 1. Midwestern University Chicago College of Osteopathic Medicine, Downers Grove, IL, United States. 2. Windsor University School of Medicine, Cayon, Saint Mary Cayon Parish, Saint Kitts and Nevis. 3. The University of Arizona College of Medicine Tucson, Tucson, AZ, United States. Clinical Research: Epidemiology and Observational Research