Concomitant skin conditions and comorbidities in Black/African American patients with rosacea
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Presented at: Society for Investigative Dermatology 2025
Date: 2025-05-07 00:00:00
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Summary: Abstract Body: Rosacea is often underdiagnosed in patients with skin of color, leading to symptom progression, hyperpigmentation, and negative impact on quality of life. Systemic comorbidities are also correlated with rosacea, potentially contributing to poor health outcomes. This study investigates concomitant cutaneous conditions and systemic comorbidities in Black/African American patients with rosacea, compared to non-Black/African American patients with rosacea. A retrospective cohort study using de-identified patient data from the TriNetX US-Collaborative Network was conducted. Propensity matching was performed to control for age and sex. Risk ratios were calculated and evaluated for statistical significance. Both propensity-matched cohorts had 13,217 patients each. The mean age for each cohort was 52.4±17.8. Each cohort had 10,687 females (80.8%) and 2,530 males (19.2%). Black/African American patients with rosacea were at higher risk for developing the following concomitant cutaneous conditions than non-Black/African American patients with rosacea, including: postinflammatory hyperpigmentation: RR=5.201, 95% CI=(4.267, 6.339), hidradenitis suppurativa: RR=2.754, 95% CI=(2.092, 3.626), atopic dermatitis: RR=2.152, 95% CI=(1.876, 2.469) and acne: RR=1.457, 95% CI=(1.335, 1.590). Black/African American patients with rosacea were at higher risk for developing systemic comorbidities than non-Black/African American patients with rosacea, including lupus erythematous: RR=2.207, 95% CI=(1.497, 3.254), and type 2 diabetes mellitus: RR=2.006, 95% CI=(1.815, 2.217). Black/African American patients with rosacea face a significantly higher risk of developing concomitant cutaneous conditions and systemic comorbidities, particularly postinflammatory hyperpigmentation, hidradenitis suppurativa, and lupus erythematosus. This underscores the need for greater awareness and timely diagnosis among the African American community. Anagha Thiagarajan<sup>1</sup>, Jack Woll<sup>1</sup>, Makenna C. Chapman<sup>1</sup>, Gabrielle Baker<sup>1</sup>, Milan M. Hirpara<sup>1</sup>, Natasha Mesinkovska<sup>1</sup> 1. University of California Irvine Department of Dermatology, Irvine, CA, United States. Minoritized Populations and Health Disparities Research