Impact of race on survival of patients with primary cutaneous CD30+ T-cell lymphoproliferative disorders: A longitudinal analysis of the SEER database (1988-2011)

Summary: Abstract Body: Introduction: Primary cutaneous CD30+ T-cell lymphoproliferative disorders (PCLPD) account for 25-30% of primary cutaneous T-cell lymphomas. Prior studies identified Black race, higher clinical stage, and receipt of chemotherapy as predictors of poor outcome. Data examining differences in racial disparity outcomes are limited. Objective: We aim to examine racial disparities in survival outcome of PCLPD over time. Methods: We examined survival patterns for PCLPD using the Surveillance Epidemiology and End Results database (code 9714/9718) from 1994-2011. Cases were divided into two cohorts based on the year of diagnosis: 2000–2005 and 2006–2011. Univariable and multivariable analyses were conducted to assess for factors associated with overall survival. Nonparametric estimates of survival distribution functions, Kaplan-Meier survival curves, and Cox proportional hazards model were used to examine factors affecting survival time. Results: 294 cases of PCLPD were identified with a median follow-up of 60 months from 1994-2011. The survival of Black patients was not inferior to White (p=0.7218) or Asian (p=0.9919) from 2000-2005. There was no difference in survival across races (p=0.9676) from 2006-2011. The survival of Black patients was not inferior to White (χ2=1.2, p=0.8994) from 1994-2011. Conclusions: We demonstrate that Black race was not correlated with worse survival in PCLPD. This contrasts with previous analysis of mycosis fungoides where Black race was associated with worse survival (Soror et al. Blood 2021). The reason for this is unclear but may be due to a smaller sample size and different disease. Britney A. Le¹, Noha Soror², Catherine Chung³, Hamid Ismail⁴, Basem William⁵ 1. Ohio University Heritage College of Osteopathic Medicine Dublin, Dublin, OH, United States. 2. The University of Oklahoma College of Medicine Alumni Association, Oklahoma City, OK, United States. 3. Dermatology, The Ohio State University College of Medicine, Columbus, OH, United States. 4. Computational Data Science and Engineering, North Carolina Agricultural and Technical State University, Greensboro, NC, United States. 5. Hematology Oncology, OhioHealth, Columbus, OH, United States. Minoritized Populations and Health Disparities Research