Impact of skin blemishing on self-confidence counteracted by an innovative chamomilla recutita extract

Summary: Abstract Body: GenZ & Millenials beauty are driven by social media (Tiktok, Instagram), the skin must be perfect uniform, pores refined, without any imperfections. This quest for perfection decreasing their self-confidence and therefore, increase resort to invasive solution as micro-Botox injections to tighten pores, control sweat production and avoid skin imperfections. To prevent from such treatment, high-tech Chamomilla recutita leaf and flower extract (CE), with effects on skin relaxing and hyperpigmentation, has been developed and designed using Ashland’s Zeta Fraction™ technology. Preliminary studies showed that CE counteract the overexpression of lipids in sebocytes of different ethnicities induced by different exposomes factors and help to reduce sebum secretion, in vivo. Here, the aim of this study was to demonstrate the effect of CE on smoothen skin flaws (uneven skin tone, dilated pores, hyperpigmentation) impacted self-confidence. First, the lipase activity on c.acnes was tested with CE which reduces the activity of the lipase thus to control the virulence of c.acnes. Then, the inflammation and appearance of pigment spots induced by c.acnes were evaluated after application or not of CE. The application of c.acnes on ex-vivo skin induces a cutaneous inflammation which has as consequence hyperpigmentation from different ethnicities countered by CE. Finally, to demonstrate in vivo, the efficacy of the extract on skin blemishing, two clinical studies were performed on different ethnicities (Caucasian and Asian skins). After 1 month of application with cream containing the extract at 1%, pores were significantly less dilated with an improvement in skin evenness compared to placebo. Likewise, hyperpigmentation was reduced for the side treated with 1% CE containing cream compared to placebo side. Skin blemishing has a real negative impact on self-confidence accentuated by social media. Applications of Chamomilla recutita extract help to improve self-confidence by limiting skin flaws as skin hyperpigmentation and obvious pores. Yolène Ferreira¹, Christelle Plaza¹, Marianne Arcioni¹, Celine Meyrignac¹, Catherine Serre¹, Isabelle Imbert¹ 1. Ashland Global Specialty Chemicals Inc, Covington, KY, United States. Translational Studies: Cell and Molecular Biology