The association of hidradenitis suppurativa and endometriosis: A cross-sectional study using the All of Us research program

Summary: Abstract Body: Hidradenitis Suppurativa (HS) and endometriosis are inflammatory disorders that greatly impact patients’ lives. Despite the overlap in inflammatory pathways in HS and endometriosis, the potential relationship between the two has not been well characterized. We sought to examine this association with a cross-sectional study using data from the National Institutes of Health’s All of Us Research Program, which focuses on traditionally underrepresented populations in research. Electronic health record and survey data of participants assigned female at birth aged over 60-years-old was used to compare the odds of having endometriosis in patients with HS versus those without via logistic regression and adjusted for demographic factors, smoking, body mass index (BMI) and common comorbidities. In this diverse cohort, 7.0% of those with HS and 2.6% of those without HS had endometriosis (P <0.001). The odds of those with HS having endometriosis was significantly higher than in patients without HS (odds ratio 2.59, 95% confidence interval 1.48-4.23, P < 0.001) even after adjusting for covariates. These findings indicate a positive association between HS and endometriosis and that suggest future research is needed to better understand whether certain therapies may be best for those with both conditions. Christine M. Hodelin¹, Anna Eisenstein², Jeffrey M. Cohen^{2, 3} 1. Yale University School of Medicine, New Haven, CT, United States. 2. Dermatology, Yale University School of Medicine, New Haven, CT, United States. 3. Biomedical Informatics and Data Science, Yale University School of Medicine, New Haven, CT, United States. Clinical Research: Epidemiology and Observational Research