Biologic immune pathway modulators in dermatology: A patent landscape analysis
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Presented at: Society for Investigative Dermatology 2025
Date: 2025-05-07 00:00:00
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Summary: Abstract Body: Biologic immune modulators, which selectively target key cytokines and signaling pathways, have greatly enhanced the management of inflammatory and autoimmune skin conditions. This study aims to categorize and analyze patents for biologic treatment in dermatology. The Lens database is an open and secure source for all patents. It was used to identify 2,699 granted patents referencing interleukins (IL), Janus kinases (JAK), or tumor necrosis factor (TNF) in conjunction with psoriasis, eczema, atopic dermatitis, seborrheic dermatitis, rosacea, acne, alopecia, hidradenitis suppurativa, urticaria, or lichen planus. After excluding non-dermatological patents, 624 patents for biologics remained which were categorized into six distinct groups (TNF-α, Th2 interleukins, JAK inhibitors, Th17 interleukins, all other IL Pathways, and all other non-IL immunomodulators). Biologics modulating the Th17 axis represented 10% of the patents. Modulation by biologics through the Th2 axis accounts for another 17% of all patents. 22% of patents for biologics fell into those that target and inhibit IL-1/L-2/IL-6/IL-10/IL-11/IL-21, the alternative IL category. 6% of the patents for biologics inhibited the TNF-α pathway. The JAK inhibitor biologics accounted for 15% of all biologics. Finally, all of the other biologic immunomodulators that inhibit pathways not mentioned, including phosphodiesterase inhibitors, account for 30% of all biologics. Collectively, these findings indicate a broad patent landscape for immune pathway modulators in dermatology, covering both well-characterized cytokine pathways and novel therapeutic approaches aimed at inflammatory skin conditions. Dev Patel<sup>1</sup>, Salwa Najmi<sup>1</sup>, Omar Alani<sup>1</sup>, Samer Wahood<sup>2</sup>, Dany Alkurdi<sup>1</sup>, Keshav Sharma<sup>3</sup>, Diya Patel<sup>1</sup>, Katie A. O’Connell<sup>4</sup> 1. Icahn School of Medicine at Mount Sinai, New York, NY, United States. 2. Brown University Warren Alpert Medical School, Providence, RI, United States. 3. Wayne State University School of Medicine, Detroit, MI, United States. 4. Vanderbilt University Medical Center, Nashville, TN, United States. Clinical Research: Epidemiology and Observational Research