Skin longevity breakthroughs and targets for cellular age reversal: Sirtuins, key epigenetics regulators

Summary: Abstract Body: In longevity research, Sirtuins have been demonstrated to extend cellular lifespan, but even more importantly, to extend healthspan as they have been shown to address impact all hallmarks of aging. Sirtuins are a family of 7 proteins. They are also epigenetic regulators that are located in strategic organelles in cells to respond to any attacks by reducing damage and optimizing cellular repair. Inspired by the potential of these Sirtuin proteins, we have undertaken more than 15 years of research to understand their impact on skin cell lifespan and healthspan and helping skin cells fight aging. Here, we show our discoveries on the importance of Sirtuins on overall skin cell healthspan and longevity and how breakthrough technologies can support Sirtuins, resulting in skin cells acting younger, thereby moving anti-aging to cellular age reversal. Earl Goyarts¹, Krystle Corallo¹, Kelly Dong¹, Jacqueline Trivero¹, Nadine Pernodet¹ 1. Research & Development, Estee Lauder Companies, Melville, NY, United States. Stem Cell Biology, Tissue Regeneration and Wound Healing