Cannabidiol as a potential sunscreen additive: A survey of peer-reviewed literature.

Summary: Abstract Body: Cannabidiol (CBD), a non-psychoactive phytocannabinoid from Cannabis sativa, has demonstrated antioxidant, anti-inflammatory, and cytoprotective properties, making it a promising candidate as a sunscreen additive. A survey of recent peer-reviewed scientific literature across electronic databases was conducted in 2024 to identify studies for a scoping review of CBD properties. In total, 19 peer-reviewed articles were examined to explore the potential of CBD in preventing UV damage. CBD exhibited antioxidant effects by decreasing reactive oxygen species and free radicals, activating the Nrf2 pathway, preventing lipid peroxidation, and stabilizing lipid membranes. Additionally, CBD reduced inflammation by inhibiting NFκB, while activating PPARγ and the endocannabinoid system. Studies further suggested that CBD may be cytoprotective and modulates apoptosis, while also enhancing melanogenesis through MAPK signaling, thereby strengthening the natural UV-protective barrier provided by melanin. CBD’s compatibility with existing mineral and chemical sunscreens could enhance function, offering both primary UV protection and secondary skin repair benefits. Though not a comprehensive search, the assessed literature largely emphasized preclinical studies, with human clinical trials needed to confirm long-term safety, tolerability, and efficacy. Given the recent consumer demand for CBD products and enthusiasm for exploring novel naturally derived compounds in skincare, CBD and its reported properties present important avenues for further research in photoprotection. Subsequent synthesis of quantitative findings and robust meta-analyses could advance CBD research and contribute to innovative strategies in sunscreen development and skin cancer prevention. George G. Papadeas¹, Mindy Szeto², Madison Reed³, Adrina Paul⁴, Taylor M. Runion⁵, Jarrett Anderson⁶, Robert Dellavalle² 1. Ohio University Heritage College of Osteopathic Medicine, Athens, OH, United States. 2. Dermatology, University of Minnesota Medical School, Minneapolis, MN, United States. 3. A T Still University, Kirksville, MO, United States. 4. Dermatology, Henry Ford Health System, Detroit, MI, United States. 5. Rocky Vista University College of Osteopathic Medicine, Parker, CO, United States. 6. Dermatology, Trinity Health Livingston, Ypsilanti, MI, United States. UV Biology/Injury and Non-melanoma Cancers