Improvement of facial beauty of elderly panelists by a non-invasive cosmetic approach using a miniprotein

Summary: Abstract Body: One of the most easily recognized aspects of beauty is the shape of the face, which can convey age, gender, and attractiveness. In women, an oval facial shape is considered attractive; however, this structure is significantly altered with age due to skin laxity. One solution to preserve or restore an oval face shape is the use of dermal fillers as an invasive aesthetic approach. In our work, we propose a non-invasive cosmetic alternative based on the topical application of a miniprotein. The objective of this work was to demonstrate the efficacy of this miniprotein to preserve and/or restore the aesthetic aspects of the faces of aged panelists. A double-blind, placebo-controlled, split-face clinical trial was conducted on 33 healthy Caucasian women before and after 14 days, 1 month, and 2 months of topical product use. The oval face improvement parameter was determined by measuring facial sagging area and by image illustrations.The biomechanical properties of the face skin area were determined by skin stiffness parameter (EasyStiff® device). The study's results confirm the efficacy of the miniprotein in improving facial sagging. The Facial sagging area parameter measured showed that after two months of miniprotein application, the shape of the face is improved. These results confirm the ability of the miniprotein to combat the aging process. These outcomes were further substantiated by images. Additionally, biomechanical assessments indicated that the miniprotein led to enhancement in skin stiffness. The results presented here demonstrates the effectiveness of the miniprotein in enhancing the aesthetic appearance of the facial skin in aged subjects. Hanane Chajra¹, Thibaut Saguet¹, Corinne Granger², Lionel Breton³, Marta Ferreira ⁴, Gael Runel ⁵ Mickaël Machicoane¹, Jean-Marc LeDoussal¹ 1. ACTIVEN, Lausanne, Switzerland. 2. Stella Polaris Europe, Paris, France. 3. Cilia Consulting, Paris, France. 4. Inovapotek, Porto, Portugal. 5. Biomeca, Lyon, France. Clinical Research: Interventional Research