Analysis of race in time to keratinocyte carcinoma in solid organ transplant recipients: Results of a single-institution study.
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Presented at: Society for Investigative Dermatology 2025
Date: 2025-05-07 00:00:00
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Summary: Abstract Body: Organ transplant patients are at an increased risk of developing keratinocyte carcinomas (KC), including squamous and basal cell carcinomas (SCC/BCC). The risks of developing KCs include type of immunosuppression, years since transplantation, race, male sex, smoking, and age at transplantation. Our study analyzes the timelines and risks of KCs in white versus non-white patients (i.e. Black, Hispanic, Asian, other) utilizing a database of 10,767 solid organ transplant recipients at Mount Sinai Health System. In our cohort, 2.3% (n=248) developed SCC and 2.1% (n=229) developed BCC, with white patients exhibiting increased odds of developing both SCC (OR = 5.75, 95% CI: 4.21-7.79, p < 0.001) and BCC (OR = 10.16, 95% CI: 7.09-15.01, p < 0.001) when compared to non-whites. These increased odds were seen at all transplant age groups. However, the time to KC diagnosis following transplantation exhibited no significant difference between white and non-white patients. These results were seen in SCC, BCC, and melanoma within our cohort. Our findings suggest that although non-white patients had decreased risk of developing KC overall, they developed them within a similar timeframe as their white counterparts. Thus, these patients should not necessarily undergo different onset or frequency of skin cancer screenings. Future work on understanding intrinsic factors relating to the time course of skin cancer development will help elucidate the frequency and timing of skin cancer screenings. Isabel C. Silva<sup>1, 2</sup>, Abiha Kazmi<sup>1, 3</sup>, Mary G. Hren<sup>1, 4</sup>, Andrew Ji<sup>1</sup> 1. Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, United States. 2. Rutgers New Jersey Medical School, Newark, NJ, United States. 3. SUNY Downstate Health Sciences University College of Medicine, New York, NY, United States. 4. Stony Brook Medicine, Stony Brook, NY, United States. Clinical Research: Epidemiology and Observational Research