Comorbidities associated with sézary syndrome: A case-control study in the All of Us database

Summary: Abstract Body: Sézary syndrome (SS) is a rare aggressive leukemic variant of cutaneous T-cell lymphoma characterized by malignant T-cells in the skin. Its etiology remains unclear. This study aimed to explore the comorbidities associated with SS utilizing All of Us, a database of 413,000 patients. Each case of SS was matched to age-, race-, and sex-matched controls. We identified the most associated conditions in patients with significance and calculated the odds ratios (ORs) with 95% confidence intervals using logistic regression. The All of Us demographics included 49 patients: 51% female, 49% male; 59.2% White, 26.5% African American, and 6% Hispanic/Latino. We identified relevant comorbidities that were most common in patients and with a high odds ratio. Analysis revealed that patients with SS had significantly elevated comorbid conditions. Cardiovascular comorbidities included hypertension (OR: 11.7), cardiac arrhythmias (OR: 6.5), and thrombocytopenic disorders (OR: 13.8). Autoimmune conditions such as IBD (OR: 17.7) and Type 1 diabetes (OR: 5.5) had significant associations. Psychiatric conditions associated with SS include depression (OR: 3.9) and anxiety disorders (OR: 3.7). Significant pulmonary diseases were COPD (OR: 5.4) and acute respiratory infection (5.25). The most common dermatological conditions associated with SS were inflammatory dermatitis (OR: 10.1), psoriasis (OR: 19.8), rosacea (OR: 5.17), and atopic dermatitis (4.78). Significant types of cancers included diffuse Large B-cell lymphoma (OR: 53.4) and Hodgkin’s disease (OR: 93.5). The comorbidities presented such as hypertension, Hodgkin’s disease, and depression have been published in the literature, but other comorbidities such as psoriasis and rosacea that may be significant were not documented in the literature. This study highlights that SS is associated with a substantial comorbidity burden, including cardiovascular, autoimmune, psychiatric, pulmonary, and dermatologic conditions. Future studies would benefit from including these comorbidities in an analysis of SS. Jeffrey Chen¹, Henry K. Wong^{1, 2} 1. Dermatology, University of California San Diego, La Jolla, CA, United States. 2. Dermatology, VA San Diego Healthcare System, San Diego, CA, United States. Clinical Research: Epidemiology and Observational Research