NEW VARIANT OF FIBROUS PAPULE CONTAINING GANGLION-LIKE CELLS: CASE REPORT AND LITERATURE REVIEW

Summary: BACKGROUND: Fibrous papules are common, benign lesions that appear on the face among middle-aged adults. Although several histologic variants have been described including epithelioid-cell, clear-cell and granular-cell types, ganglion-cell type is not generally seen. METHODS: We report the unique case of fibrous papule with ganglion-like cells, describe morphologic features of this variant and emphasize its similarities with other soft-tissue neoplasms containing pleomorphic cells. Database search of PubMed, Scopus, and Google Scholar was conducted to review other reports of these rare neoplasms. RESULTS: We found only one other published report of fibrous papules containing ganglion-like cells. This variant has not been well-elaborated and should be considered a distinct subtype. CONCLUSION: The differential diagnosis of cutaneous lesions with ganglion-like cells should be expanded to include fibrous tumors in order to avoid misdiagnosing malignant processes that may lead to unnecessary procedures.