Spatial clustering and phenol exposure in vitiligo: A cross-sectional analysis of the United States
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Presented at: Society for Investigative Dermatology 2025
Date: 2025-05-07 00:00:00
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Summary: Abstract Body: Background:Chemical exposure may serve as an environmental risk factor for vitiligo. Most known vitiligo-inducing chemicals are phenols, acting as tyrosine analogs that disrupt melanin production and trigger melanocyte destruction. However, studies examining spatial relationship between phenol exposure and vitiligo are lacking. Methods:We conducted a nationwide cross-sectional study of adults in the 2017-2022 All of Us database. Geographic data was extracted from subjects’ 3-digit residential zip code prefixes. Phenol release data from the Environmental Protection Agency was assigned to zip code areas within a 5km radius of phenol-releasing facilities. Exposure levels were classified as none, low( Li-Chi Chen<sup>1</sup>, Ta-Chien Chan<sup>2</sup>, Tyler J. Long<sup>1</sup>, Todd F. Pearson<sup>1</sup>, John E. Harris<sup>1</sup> 1. UMass Chan Medical School, Worcester, MA, United States. 2. Academia Sinica, Taipei, Taiwan. Pigmentation, Melanoma, and Melanoma Immune Surveillance