Advancing skin health and longevity through targeted metabolic activity optimization

Summary: Abstract Body: Background: The progression of skin aging is marked by a distinct metabolic shift. In youth, skin cells exhibit robust production of structural proteins like collagen and elastin. However, as we age, cellular metabolism pivots towards heightened inflammation and increased generation of reactive oxygen species. This metabolic alteration leads to cellular dysfunction, particularly affecting mitochondrial health, and ultimately propels cells towards senescence. This transition from a constructive to a potentially destructive cellular environment is a hallmark of the skin aging process. Objective: Our research explored the age-dependent metabolic alterations and their cascading effects on various aspects of cellular health. We examined the correlation between these metabolic shifts and key biofunctional markers in skin, with a particular focus on indicators of cellular senescence and extracellular matrix (ECM) composition. Results & Conclusion: Age-related changes in fibroblasts are characterized by various phenotypic attributes at the cellular level. We found that fibroblasts undergo age-associated metabolic reprogramming, characterized by heightened metabolic activity. This metabolic shift demonstrates a strong correlation with diverse biofunctional indicators in the skin. Strategic modulation of these metabolic alterations may potentially preserve and promote the maintenance of a youthful skin appearance. Manpreet Randhawa¹, Krys Bojanwoski², Rahul Mehta¹ 1. Rapalogix Health Inc, New York, NY, United States. 2. Sunny Biodiscovery, Santa Paula, CA, United States. Translational Studies: Preclinical