Formulation and activity of a topical product with hyperfermented extract of kazanlink rose petals encapsulated in liposomes

Summary: Abstract Body: This work was aimed to study the stability, and the activity of topical products formulated with hyperfermented extract of Kazanlink Rose petals encapsulated in liposomes, produced in Chianti (Tuscany-Italy). Recent studies have suggested a possible moisturizing and elasticizing activity of extract of Kazanlink Rose. For such characteristics hyperfermented extract of Kazanlink Rose petals encapsulated in liposomes appears an appropriate ingredient to be used in topical preparations for the treatment of skin hydration. On these bases we evaluated the activity of 4 gel preparations, respectively, containing: (a) gel without active ingredients as control, (b) gel containing liposomes without active ingredients, (c) gel with 3% of hyperfermented extract of Kazanlink Rose petals encapsulated in liposomes, (d) gel with 3% of hyperfermented extract of Kazanlink Rose petals. The investigation was carried out on 10 healthy male and female volunteers, between the ages of 32 and 66, with normal or dry skin. Each product was applied to the volar surface of the forearm at a dose of 3 mg/cm2. As control, the same cream without active ingredient was applied to the other forearm. To evaluate TEWL was used the device Moisture Meter Epid Delfintech®, and skin elasticity was evaluated with Elasti Meter Delfintech®. The skin hydration action of the formulations was evaluated in relation to basal value, and the formulations without active ingredient, respectively after 15 minutes and 15 days. The skin elasticity was evaluated after 15 minutes and 15 days. The results showed that the gel with hyperfermented extract of Kazanlink Rose petals encapsulated in liposomes, compared to the gel formulation without active ingredients, significantly increase the degree of hydration and elasticity of the skin, both short and long term. Marco Andreassi¹, Corrado Salvini¹, Alessandro Domini¹, Claudia Bonechi¹, Gabriella Tamasi¹, Marco Consumi¹, Gemma Leone¹, Flavia Bisozzi¹, Agnese Magnani¹, Claudio Rossi¹ 1. Department of Biotechnology, Chemistry and Pharmacy, Universita degli Studi di Siena, Siena, Tuscany, Italy. Translational Studies: Preclinical