Multi-modal barrier repair cream: Harnessing the power of the skin’s circadian rhythm

Summary: Abstract Body: A barrier repair cream (BRC) was formulated to target the symptoms and source of skin barrier dysfunction in dry to very dry and sensitive skin. Containing microbiome, hydrolipid, tight junction, and circadian rhythm technology, the BRC was developed to optimize daytime defense and nighttime regeneration, thereby supporting skin health and resilience. To evaluate the efficacy and tolerability of the BRC, three studies were conducted involving females with dry skin: 1) Corneometer (24-hour; controlled; leg; single application), 2) Tewameter (14-day; randomized; cheek; sensitive skin; twice-daily application), and 3) consumer preference study (BRC vs. competitor barrier creams; randomized/blinded/split-face; self-perceived moderate to severe dry skin; single application). Each study had 35, 22, and 23 subjects complete, respectively. Stratum corneum water content statistically significantly improved through 24 hours, with 70% and 40% increases after 1 and 8 hours, respectively (p<0.001). TEWL decreased by 14% after 14 days (p=0.004), and 91% of subjects agreed the BRC “alleviates my dry skin” and “my skin is soothed and calmed.” The BRC was also well-tolerated and well-perceived. Furthermore, 73% and 58% of subjects preferred the BRC over two competitor creams, respectively. The improvements in skin hydration and barrier integrity are linked to the BRC’s comprehensive formulation targeting multiple factors in skin barrier dysfunction, with the skin’s circadian rhythm as a key approach. Overall, the BRC is an intensely hydrating barrier repair treatment suitable for dry and sensitive skin that was also preferred over competitor creams targeting the symptoms and not the source of dry skin. This work was funded by the manufacturer of the BRC. Morgann Young¹, Brittony Croasdell², Tatiana Kononov¹, Alisar Zahr¹ 1. Revision Skincare, Irving, TX, United States. 2. Fulcrum Aesthetics, Chicago, IL, United States. Epidermal Structure and Barrier Function