Risk of cardiovascular events among cutaneous T-cell lymphoma patients in the TriNetX database

Summary: Abstract Body: We aimed to characterize cardiovascular (CV) comorbidities in Cutaneous T-cell Lymphoma (CTCL), a disease with an unexplored comorbidity risk profile. CTCL has clinical and pathophysiological similarities to benign inflammatory dermatoses (BID), which are associated with elevated risk of CV diseases attributed to systemic inflammation. Data was extracted from the TriNetX database for 23,145 CTCL patients (22,245 w/o concurrent BID), 1,856,614 BID patients, and 11,268,027 healthy controls (HC) (visit w/o abnormal findings, ICD-10: Z00.00). All groups were mutually exclusive, excluding those with CV conditions diagnosed before index CTCL/BID/HC diagnosis. Prevalence of CV disease after CTCL diagnosis was compared to HC/BID using descriptive statistics, Kaplan-Meier analyses, and Cox Proportional (CP) Hazard models with age, sex, ethnicity/race, and prior diagnosis of diabetes mellitus, obesity/overweight, nicotine dependence, or alcohol related disorder as covariates. CTCL patients had higher risk of clots (CPHR=1.95, 95% CI 1.82-2.09), pulmonary embolism (PE) (CPHR=1.62, 1.47-1.79), cardiac arrest- unspecified cause (CA) (CPHR=1.52, 1.29-1.80) and similar risk of acute MI, versus HC. Compared to BID, CTCL patients had greater risk of clots (CPHR=1.84, 1.71 - 1.98), PE (CPHR=1.62, 1.47 - 1.79), CA (CPHR=1.34, 1.13 - 1.59), and slightly lower risk of acute MI (CPHR=0.86, 0.78 - 0.95). Our findings suggest an increased risk of some CV events among CTCL patients, with an almost twofold risk ratio increase for clots, versus those with BID/HC. While recognizing limitations of the TriNetX database, this work represents a novel investigation of CTCL comorbidities in a dataset of this size and prompts further consideration of hypercoagulability screening, prophylaxis, and management strategies in this vulnerable population. Sara Suhl¹, Abigail Marx¹, Zachary Neubauer², Alexander Kaminsky¹, Julie Sung³, Shari Lipner⁴, Larisa J. Geskin³ 1. Columbia University Vagelos College of Physicians and Surgeons, New York, NY, United States. 2. Thomas Jefferson University Sidney Kimmel Medical College, Philadelphia, PA, United States. 3. New York-Presbyterian/Columbia University Irving Medical Center, New York, NY, United States. 4. Weill Cornell Medicine, New York, NY, United States. Clinical Research: Epidemiology and Observational Research