Amplifying skin’s hydration for skin health and longevity

Summary: Abstract Body: Maintaining skin hydration is crucial for overall skin health, particularly in addressing facial skin aging. Hyaluronic acid (HA), a glycosaminoglycan, plays an important role in attracting and retaining moisture, thus supporting skin health and longevity. With age, endogenous HA levels decrease, accompanied by other biological and molecular changes, resulting in compromised skin health and reduced resilience. When applied topically, HA can provide immediate hydration, resulting in a plump and youthful appearance. A limitation of HA for topical delivery is its inability to penetrate deeply into the skin. To achieve both short- and long-term hydration while supporting skin health and longevity, an ultra-light, oil-free Hydration Boosting Serum (HBS) was developed. This formulation combines a unique blend of high- and medium-molecular-weight HA with an anionic polysaccharide resistant to enzymatic degradation in the skin, as well as fruit extracts; watermelon, apple, and lentil and a peptide to support the production of skin’s own natural moisturizing factors. An open-label, split-face clinical study evaluated the moisturizing efficacy of the HBS after a single application on 26 females aged 23 – 71 years with dry or mixed facial skin. Subjects were randomized to apply the HBS or untreated to the right or left side. Triplicate corneometer measurements (n=21) were performed at baseline, 15 minutes, and 2-, 6-, 8-, and 10-hours post-product application. Facial hydration mapping was performed via QIMA NEWTONE on 5 subjects. Ten locations per hemi-face were identified, and triplicate measurements were taken at baseline and 15 minutes post-application. A virtual image was then generated utilizing AI technology via Mean Face, using the average corneometer results of 5 subjects. The HBS amplified moisturizing activity of the superficial epidermal layers at post-baseline timepoints. Peak activity was achieved in 15 minutes with a 61% application in skin hydration. At 10 hours, a 40% increase was determined. Facial hydration mapping further validated skin health results. Sofia Iglesia¹, Tatiana Kononov¹, Alisar Zahr¹ 1. Revision Skincare, Irving, TX, United States. Epidermal Structure and Barrier Function