When AI helps developing an innovative anti-aging biofunctional

Summary: Abstract Body: Skin aging is one the most preoccupation of consumer. It is characterized by appearance of wrinkles, loss of elasticity, dryness due to loss of collagen, enhanced by extrinsic factors. For this reason, a new kind of biofunctional was designed by artificial intelligence (AI). This ingredient contains, a molecular complex composed of hydrolyzed sodium hyaluronate (HA) and two peptides, known for their anti-aging efficiency. These interactions were strengthened thank to a unique patented technology named 2HP™ technology and was embedded in cellulose gum matrix bringing a dual action: texturing and bioactive. In vitro studies showed a beneficial effect on the expression of 20 collagen-chains distributed in the 8 collagen families by immunohistostaining of collagen-chains as well as by immunocytostaining and qPCR in skin’s cells. These results were supported by two double-blind clinical studies. The first one, was a short-term study conducted on 30 Asian volunteers. They applied during 30 min a mask embedded with 5% biofunctional on one side or with placebo on the other side. 30 min after mask removal, the skin was significantly more hydrated with a better elasticity. After 4h, fine lines were smoothness with better skin glower compared to placebo keeping the effect on hydration and elasticity. The second study was a long-term study carried out on 34 volunteers divided in two homogeneous groups. Both groups applied a cream containing 5% biofunctional or its placebo for 1 month. Since D14, the skin was more hydrated with a smoother and softer skin. After one month of applications, with the biofunctional containing cream, the main wrinkles significantly decreased in circumference and depth. Likewise, the skin elasticity was improved while still having better hydration compared to placebo. In this study, we investigated the in vivo effect of this new ingredient from 2HP™ technology and having a dual action. These results highlighted short and long-term effects on skin hydration and aging. Yolène Ferreira¹, Ludivine Mur¹, Isabelle Imbert¹ 1. Ashland Global Specialty Chemicals Inc, Covington, KY, United States. Translational Studies: Cell and Molecular Biology