Summarizing current core assessment domain establishment efforts

Summary: Abstract Body: International efforts coordinated by the Core Outcome Measures in Effectiveness Trials (COMET) Initiative have sought to understand what outcomes are critical for adequative assessment in a given setting (clinical trials, etc). One of the initial stages of this process is understanding what domains are important to measure from the perspective of patients and experts. Using COMET-Initiative’s database of current efforts we summarized domains evaluated and how recommendations for these varied across patients and clinicians. We identified 25 studies that specifically sought to identify core assessment domains across a broad range of inflammatory and lesional skin conditions. The domains most often assessed included clinical signs/symptoms (19/25), quality of life (16/25), symptoms (15/25), maintenance of effect (14/25), and adverse events (14/25). When comparing patient and expert scoring, patients tended to numerically score mental health and emotional impact-related domains higher. Clinicians numerically scored clinician assessments higher. Common final accepted domains included: quality of life, symptoms, clinical signs/appearance, disease maintenance, global assessments, adverse events, and treatment satisfaction. In the clinical setting, efforts should be made to assess core domains, but these must be efficient and feasible. These summarized data can guide these efforts by highlighting common domains that cross-cut multiple diseases and highly favored by patients and clinicians. Likewise, these may highlight domains that may be of clinical importance but weren’t accepted such as psychological well-being which tended to be more recommended by patients than clinicians. Dallin Ringworm¹, Meg Ringworm¹, Mark Conley², Zachary Frost¹, Zachary Ney³, Aaron Secrest⁴, Jacob Kean⁵, Zachary Hopkins⁴ 1. Noorda College of Osteopathic Medicine, Provo, UT, United States. 2. University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, United States. 3. The University of Utah School of Medicine, Salt Lake City, UT, United States. 4. Dermatology, The University of Utah School of Medicine, Salt Lake City, UT, United States. 5. Population Health Sciences, The University of Utah School of Medicine, Salt Lake City, UT, United States. Clinical Research: Epidemiology and Observational Research