The Use of MRI Guided Hypofractionated Radiation to Improve Compliance and Minimize Toxicity in Locally Advanced Cervical Cancer

Summary: Hypofractionated radiation therapy has become standard of care option in many disease sites. There are limited series evaluating hypofractionated RT in patients with cervical cancer with some success, with an ongoing Canadian prospective trial evaluating the feasibility of hypofractionated CT-based radiotherapy; however, MRI-guided hypofractionated pelvic RT has not yet been explored. This study will asses if hypofractionated MRI-guided pelvic RT will lead to smaller treatment volumes, decreased acute and late toxicity, improved compliance, and improved patient reported outcomes. It will also evaluate radiomic tumor features and circulating tumor cells and then correlate to patient outcomes.