The skin-brain connection: How mental health impacts dermatological conditions

Summary: Recent dermatological research is uncovering new insights into the intricate connection between the skin and the brain, emphasizing the brain's profound impact on skin health and dermatological symptoms. Studies have shown that psychological stress, anxiety, and depression can significantly exacerbate various skin conditions, such as acne, eczema, and psoriasis. Neurotransmitters and hormones released by the brain, such as cortisol and substance P, can influence inflammatory pathways in the skin, leading to increased sensitivity, irritation, and flare-ups of existing dermatologic issues. Furthermore, the brain’s regulation of immune function plays a pivotal role in developing and progressing conditions like atopic dermatitis and psoriasis. Integrating neurodermatology into dermatological practice offers a more comprehensive approach to patient care, where mental health and stress management are considered key components in managing chronic skin conditions. This review examines how the brain influences skin health and leverages this connection to improve treatment outcomes, emphasizing the importance of a multidisciplinary approach that combines dermatology, mental health interventions, and the skin-brain axis. Ongoing research focuses on developing therapies that target both the brain and skin, offering the potential for more effective treatments that address the root causes of dermatological symptoms. Future directions will look into integrating mental health care into dermatology for holistic, personalized skin care and healing approaches. Behzad Maher¹, Donia Javidi¹ 1. California Health Sciences University College of Osteopathic Medicine, Clovis, CA, United States. Cell Communication Networks and Stromal Biology