Integrating nutrition and the gut-skin axis into dermatology: A holistic approach to skin health and rejuvenation

Summary: Recent studies show that the gut-skin axis is significant in maintaining skin health, particularly in anti-aging, collagen synthesis, and rejuvenation. The gut microbiome regulates inflammation, immune responses, and skin barrier function, all critical in supporting youthful, healthy skin. Diets rich in vitamins, minerals, antioxidants, and omega-3 fatty acids help reduce oxidative stress, support collagen production, and combat inflammation. A balanced diet can help maintain the skin’s structure and external appearance by supporting internal processes that regulate skin health. The gut-skin axis suggests that a healthy gut microbiome influences skin conditions. Diets high in fiber, fermented foods, and prebiotics support beneficial gut bacteria, reducing inflammation and improving skin barrier function. In contrast, diets rich in processed foods and unhealthy fats contribute to gut dysbiosis, which can exacerbate conditions like acne, rosacea, and eczema. Many species, such as Cutibacterium acnes, Staphylococcus epidermidis, and Malassezia, on the skin are affected by gut health imbalances, influencing skin inflammation and irritation. Probiotics, found in foods like yogurt and kefir, can help restore balance to the gut microbiome, further supporting skin health. Integrating nutrition-focused therapies into dermatology offers a holistic approach to skincare. This review explores how personalized nutrition and microbiome-focused therapies can enhance dermatological treatments, offering an integrative approach to skin rejuvenation. As research continues, evidence-based nutritional guidelines will play a pivotal role in optimizing skin health, addressing both internal health and external appearance for more sustainable, effective skincare solutions. Noor Javidi¹, Donia Javidi² 1. Bastyr University California - San Diego Campus, San Diego, CA, United States. 2. California Health Sciences University College of Osteopathic Medicine, Clovis, CA, United States. Innate Immunity, Microbiology, and Microbiome