Sleep and activity in skin of color patients with autoinflammatory conditions

Summary: Chronic inflammatory and autoimmune skin conditions are associated with sleep disturbances and decreased physical activity, which can significantly impact quality of life. Skin of color (SOC) patients with these conditions have lower quality of life even after controlling for disease severity and body surface area affected. Our study uses biometric data to compare sleep and activity quality in SOC vs. non-SOC patients with these conditions. A secondary objective is to determine if biometric data is correlated to patient reported data. Biometric data from wearable devices and patient questionnaire data for patients with psoriasis, hidradenitis suppurativa, atopic dermatitis, vitiligo, lupus, alopecia areata and acne were extracted from the All of Us database. Sleep data were reviewed for 567 white patients and 72 SOC patients. In comparison to SOC patients, white patients spent 35 more minutes asleep (401 vs 365, p<0.001) and spent more minutes in light sleep (258 vs 223, p< 0.001). SOC patients spent a greater percentage of the night in deep sleep (17.3 vs 15.3, p<0.001) and a greater percentage of time in REM sleep (21.2 vs 19.9, p=0.02). Among activity data for 636 white patients and 81 SOC patients, there were no statistically significant differences in time spent being very active, fairly active, lightly active, or sedentary among these groups. Among patient reported data, white patients reported better overall health, quality of life, physical health, mental health, social ability, and physical ability (on a scale 1-5, all p values<0.001). SOC patients also reported higher pain scores (5.56 vs 4.06, p< 0.01). Our analysis demonstrates no difference in activity levels between the two groups despite white patients having better self-reported measures of health. While white patients spent more time asleep, SOC patients spent a higher percentage of the night in deep sleep and REM sleep. Further investigation is needed to explore sleep quality and impact on quality of life in these patients. Meera Kattapuram¹, Christopher Reagan², Evelyn F. Fagan¹, Joseph T. McGrath¹, Erin X. Wei¹ 1. Dermatology, University of Nebraska Medical Center, Omaha, NE, United States. 2. University of Missouri-Kansas City, Kansas City, MO, United States. Minoritized Populations and Health Disparities Research