IMMUNOEXPRESSION OF MATRIX METALLOPROTEINASES MMP 1, MM2, MMP 9 AND MMP14 IN EXTRAGENITAL ENDOMETRIOSIS AND EUTOPIC ENDOMETRIUM
Eugeniu Cazacu
Guru | Physican assistant Pathology, Cytopathology, Anatomic Pathology, Breast Pathology, Dermatopathology, Gastrointestinal Pathology, Genitourinary Pathology, Obstetrics/Gynecology Pathology, Soft Tissue/Bone Pathology, Renal Pathology, Surgical Pathology, Thoracic Pathology, Molecular Genetic Pathology, Hematopathology
Presented at: Congress of the “Nicolae Testemitanu” State University of Medicine and Pharmacy, dedicated to the celebration of 75 years of activity
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Summary: Matrix metalloproteinases are proteolytic enzymes responsible for the disorder of extracellular matrix modeling in endometriosis and their involvement in the invasion process.
The aim of this study was to evaluate the immunohistochemical expression of matrix-metalloproteinases MMP1, MMP2, MMP9 and MMP14 in surgical excision specimens, collected from women with extragenital endometriosis compared to their expression in the normal endometrium.
The study included 40 female patients diagnosed with extragenital endometriosis. The used methods consisted in processing the specimens by classical histological technique with paraffin inclusion and enzymatic immunohistochemical technique for the detection of metalloproteinases MMP1, MMP2, MMP9 and MMP14.
The expression of matrix metalloproteinases MMP2, MMP14 was significant in stromal cells from endometriotic lesions, while MMP9 was evident in both stromal and glandular cells in these lesions. The expression MMP1 was not present. Normal endometrial tissue showed high reactivity for MMP14 and low reactivity for MMP2 and MMP9.
This study reveals some aspects related to the morphological and clinical features of extragenital endometriosis with different locations and the correlation between the clinical evolution and some immunohistochemical markers with potential prognosis regarding the aggressiveness of such lesions.
Endometriosis, matrix metaloproteinases, invasiveness potential