Multiple images in this post...swipe or use arrows to see them all.
Video explanation: https://kikoxp.com/posts/15994
These are true nerve sheath tumors. They are positive for S100 and SOX-10. They sometimes have palisading, and in this case, it was so pronounced that it resembled Verocay bodies a la schwannoma.
These are not related to cellular neurothekeoma (which is actually NOT a nerve sheath tumor - complicated history and naming conundrum explained here: https://kikoxp.com/posts/4103).
Great paper on nerve sheath myxoma:
WF Fetsch, WB Laskin, M Miettinen. Nerve sheath myxoma: a clinicopathologic and immunohistochemical analysis of 57 morphologically distinctive, S-100 protein- and GFAP-positive, myxoid peripheral nerve sheath tumors with a predilection for the extremities and a high local recurrence rate. Am J Surg Pathol . 2005 Dec;29(12):1615-24. https://pubmed.ncbi.nlm.nih.gov/16327434/
More on Cellular neurothekeoma:
Video (nerve sheath myxoma vs cellular neurothekeoma 101): https://kikoxp.com/posts/4103
Video (at 35:32): https://kikoxp.com/posts/3784
Video (discussed in this review video): https://kikoxp.com/posts/4999
See also:
Dermal nerve sheath myxoma (formerly conventional/myxoid neurothekeoma)
Video (nerve sheath myxoma vs cellular neurothekeoma 101): https://kikoxp.com/posts/4103
Video (short): https://kikoxp.com/posts/4616
Video (at 56:07): https://kikoxp.com/posts/3784
Video (discussed in this review video): https://kikoxp.com/posts/4999
You might like my Twitter/social media 101 guide: https://kikoxp.com/posts/15217
A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: https://kikoxp.com/posts/5084 (dermpath) & https://kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
Please check out my Soft Tissue Pathology & Dermatopathology survival guide textbooks: http://bit.ly/2Te2haB
This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation.
Presented by Jerad M. Gardner, MD. Please subscribe to my channel to be notified of new pathology teaching videos.
Follow me on:
Snapchat: JMGardnerMD
Twitter: @JMGardnerMD
Instagram: @JMGardnerMD
Kiko: https://kikoxp.com/profile/jerad_gardner1/content?filter=popular
Facebook: https://www.facebook.com/JMGardnerMD/
Video explanation: https://kikoxp.com/posts/15994
These are true nerve sheath tumors. They are positive for S100 and SOX-10. They sometimes have palisading, and in this case, it was so pronounced that it resembled Verocay bodies a la schwannoma.
These are not related to cellular neurothekeoma (which is actually NOT a nerve sheath tumor - complicated history and naming conundrum explained here: https://kikoxp.com/posts/4103).
Great paper on nerve sheath myxoma:
WF Fetsch, WB Laskin, M Miettinen. Nerve sheath myxoma: a clinicopathologic and immunohistochemical analysis of 57 morphologically distinctive, S-100 protein- and GFAP-positive, myxoid peripheral nerve sheath tumors with a predilection for the extremities and a high local recurrence rate. Am J Surg Pathol . 2005 Dec;29(12):1615-24. https://pubmed.ncbi.nlm.nih.gov/16327434/
More on Cellular neurothekeoma:
Video (nerve sheath myxoma vs cellular neurothekeoma 101): https://kikoxp.com/posts/4103
Video (at 35:32): https://kikoxp.com/posts/3784
Video (discussed in this review video): https://kikoxp.com/posts/4999
See also:
Dermal nerve sheath myxoma (formerly conventional/myxoid neurothekeoma)
Video (nerve sheath myxoma vs cellular neurothekeoma 101): https://kikoxp.com/posts/4103
Video (short): https://kikoxp.com/posts/4616
Video (at 56:07): https://kikoxp.com/posts/3784
Video (discussed in this review video): https://kikoxp.com/posts/4999
You might like my Twitter/social media 101 guide: https://kikoxp.com/posts/15217
A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: https://kikoxp.com/posts/5084 (dermpath) & https://kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
Please check out my Soft Tissue Pathology & Dermatopathology survival guide textbooks: http://bit.ly/2Te2haB
This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation.
Presented by Jerad M. Gardner, MD. Please subscribe to my channel to be notified of new pathology teaching videos.
Follow me on:
Snapchat: JMGardnerMD
Twitter: @JMGardnerMD
Instagram: @JMGardnerMD
Kiko: https://kikoxp.com/profile/jerad_gardner1/content?filter=popular
Facebook: https://www.facebook.com/JMGardnerMD/