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Here's a case of clear cell renal cell carcinoma with rhabdoid and sarcomatoid features. Presence of any one of these morphological features automatically upgrades the tumor to grade 4. It is not uncommon that they be present simultaneously. As expected, they predict a poor prognosis.
Rhabdoid differentiation is characterized by sheets of discohesive round to polygonal cells with abundant eosinophilic cytoplasm and eccentrically placed large pleomorphic vesicular nuclei often with prominent nucleolus.
Sarcomatoid differentiation results in biphasic tumour morphology with varying amounts of fibrosarcoma-like or UPS-like patterns, as well as areas of unclassified morphology. Heterologous differentiation such as chondrosarcoma, osteosarcoma, or rhabdomyosarcoma is rare but may be seen.
There are multiple sections depicted. Use the mouse or the arrows to navigate through them and see if you can identify all of the three distinct tumor areas.
Here's a case of clear cell renal cell carcinoma with rhabdoid and sarcomatoid features. Presence of any one of these morphological features automatically upgrades the tumor to grade 4. It is not uncommon that they be present simultaneously. As expected, they predict a poor prognosis.
Rhabdoid differentiation is characterized by sheets of discohesive round to polygonal cells with abundant eosinophilic cytoplasm and eccentrically placed large pleomorphic vesicular nuclei often with prominent nucleolus.
Sarcomatoid differentiation results in biphasic tumour morphology with varying amounts of fibrosarcoma-like or UPS-like patterns, as well as areas of unclassified morphology. Heterologous differentiation such as chondrosarcoma, osteosarcoma, or rhabdomyosarcoma is rare but may be seen.
There are multiple sections depicted. Use the mouse or the arrows to navigate through them and see if you can identify all of the three distinct tumor areas.
