Details: 65, XY, upper inner thigh. Impression was papule vs. LPLK vs. CIS.
Ancillary assessment: p16+++ (Level 11).
WSI presentation.
The inspiration to complete p16 immunostaining in this instance was a desire to build a case that the diagnosis was effectively HSIL. Since the immunostain (2nd WSI) shows blazing block positivity, that mission was accomplished.
Ancillary assessment: p16+++ (Level 11).
WSI presentation.
The inspiration to complete p16 immunostaining in this instance was a desire to build a case that the diagnosis was effectively HSIL. Since the immunostain (2nd WSI) shows blazing block positivity, that mission was accomplished.
- To review a similar case at a digital site, navigate here: https://kikoxp.com/posts/16503
- To review HSIL, navigate here: https://meridian.allenpress.com/aplm/article/136/10/1266/133088/The-Lower-Anogenital-Squamous-Terminology
- Remember that when oncogenic HPV is present, Rb protein binds to HPV oncoprotein E7, which blocks Rb suppression of p16. Overexpression ensues. It's effective surrogate staining if HPV ISH is not an in-house commodity
Level 5 Expert | Fellow
July 05, 2023 at 2:20pmLevel 2 Genius | Physician
July 05, 2023 at 3:05pm