In routine bone marrow evaluation, the core biopsy is useful for assessing overall marrow cellularity, trilineage hematopoiesis, and marrow architecture.
The prepared core biopsy slides can be used for immunohistochemical (IHC) investigations (phenotyping the cells using IHC stains), and an initial standard hematoxylin and eosin (H&E) stain is done to assess baseline histology. After these initial assessments, immunostains often aim at assessing architecture, fibrosis, lymphoid aggregates, myeloid lineage maturity, and other related potential pathologies.
Often, pathology on a core biopsy can be patchy. Can you recognize which areas are abnormal in this core?
The prepared core biopsy slides can be used for immunohistochemical (IHC) investigations (phenotyping the cells using IHC stains), and an initial standard hematoxylin and eosin (H&E) stain is done to assess baseline histology. After these initial assessments, immunostains often aim at assessing architecture, fibrosis, lymphoid aggregates, myeloid lineage maturity, and other related potential pathologies.
Often, pathology on a core biopsy can be patchy. Can you recognize which areas are abnormal in this core?
Level 3 Guru | Physician Assistant
July 27, 2021 at 9:15pmLevel 3 Guru | Physician
July 28, 2021 at 11:03amplus nodules elsewhere.
I can't zoom in as much as I would like to see the morphology, but I would say small (B) cell lymphoma.