Soft tissue pathology cases with my pathology resident, Dr. Fatima Absar! Enjoy.

Topics discussed:

Epithelioid fibrous histiocytoma (EFH) (aka Epithelioid cell histiocytoma) 0:00

Dermatofibroma (lipidized "ankle-type") plus tattoo 13:40

Atypical fibrous histiocytoma (atypical dermatofibroma): 18:59
WSI digital slide: https://kikoxp.com/posts/40406 

Traumatic neuroma (and nerve histology discussion) 28:48
WSI digital slide: https://kikoxp.com/posts/8018

Nerve vs Smooth Muscle Histology 34:55

Solitary bone cyst aka unicameral bone cyst (UBC) aka simple bone cyst 38:04
WSI digital slide: https://kikoxp.com/posts/40404

Schwannoma with ancient change 46:18
WSI digital slide: https://kikoxp.com/posts/11804

Lipoma arborescens (synovial lipomatosis) 58:08
WSI digital slide: https://kikoxp.com/posts/24225

Synovial chondromatosis 1:02:20

Paraganglioma of carotid body 1:07:43


Other useful videos and links:

The salt on silk effect that makes a cartilage-type look: https://youtu.be/M5dU-WuJLj8
Tendon vs Nerve Histology Made Simple with the Ramen Noodle Sign (of Fulton) video: https://kikoxp.com/posts/4466
AFX video: https://kikoxp.com/posts/4238
ABC video: https://kikoxp.com/posts/4514 
Schwannoma 101 video https://kikoxp.com/posts/4093 
Neurofibroma 101 video: https://kikoxp.com/posts/4091
MPNST video https://kikoxp.com/posts/4092
Alveolar soft part sarcoma (vs alveolar rhabdomyosarcoma) video: https://kikoxp.com/posts/4580

Kaddu, Steven, et al. “Atypical Fibrous Histiocytoma of the Skin: Clinicopathologic Analysis of 59 Cases with Evidence of Infrequent Metastasis.” The American Journal of Surgical Pathology, vol. 26, no. 1, Jan. 2002, pp. 35–46. PubMed, https://doi.org/10.1097/00000478-200201000-00004. https://pubmed.ncbi.nlm.nih.gov/11756767/

Publications about EFH:

I was wrong. Jedrych et al was actually the first to report ALK in epithelioid fibrous histiocytoma. Doyle et al followed this up with a larger study soon after.

Jedrych, J., et al. “Epithelioid Cell Histiocytoma of the Skin with Clonal ALK Gene Rearrangement Resulting in VCL-ALK and SQSTM1-ALK Gene Fusions.” The British Journal of Dermatology, vol. 172, no. 5, 2015, pp. 1427–29. PubMed, https://doi.org/10.1111/bjd.13548. https://pubmed.ncbi.nlm.nih.gov/25413595/

Doyle, Leona A., et al. “ALK Rearrangement and Overexpression in Epithelioid Fibrous Histiocytoma.” Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc, vol. 28, no. 7, July 2015, pp. 904–12. PubMed, https://doi.org/10.1038/modpathol.2015.49. https://pubmed.ncbi.nlm.nih.gov/25857825/

Martinez, Anthony P., et al. “‘Chondroblastoma-like’ Epithelioid Fibrous Histiocytoma: A Previously Undescribed and Potentially Confusing Variant.” Journal of Cutaneous Pathology, vol. 45, no. 2, Feb. 2018, pp. 99–103. PubMed, https://doi.org/10.1111/cup.13068. https://pubmed.ncbi.nlm.nih.gov/29068085/

Here's our paper about dot-like ALK in EFH:
Dawson, Kellen, et al. “Epithelioid Fibrous Histiocytoma With Dot-Like Perinuclear ALK Expression and PRKAR2A-ALK Fusion.” The American Journal of Dermatopathology, vol. 42, no. 11, Nov. 2020, pp. 861–64. PubMed, https://doi.org/10.1097/DAD.0000000000001666. https://pubmed.ncbi.nlm.nih.gov/32379091/

A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: https://kikoxp.com/posts/5084 (dermpath) & https://kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).

Please check out my Soft Tissue Pathology & Dermatopathology survival guide textbooks: http://bit.ly/2Te2haB ‬

This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation.

Presented by Jerad M. Gardner, MD. Please subscribe to my channel to be notified of new pathology teaching videos.

Follow me on:
Snapchat: JMGardnerMD
Twitter: @JMGardnerMD
Instagram: @JMGardnerMD
Kiko: https://kikoxp.com/profile/jerad_gardner1/content?filter=popular
Facebook: https://www.facebook.com/JMGardnerMD/